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教师简介

逯杨
来源:伟德官网 时间:2016-12-26 12:06:08 阅读量:



职称职务:研究员

学科专业:微生物学

研究方向:病原真菌学
实验室位置:伟德官网3003、3134室
Email:ylu7@whu.edu.cn


学习经历:

2002-2008 中科院上海生命科学研究院生物化学与细胞生物学研究所,博士
1998-2002 吉林大学生物化学系,学士

主要工作经历与任职情况:
2016-至今 伟德官网,研究员,博士生导师
2013-2015 加州大学欧文分校医学院,研究助理
2008-2013 加州大学欧文分校医学院,博士后


主要研究领域及兴趣:
  目前,真菌感染随着广谱抗生素的滥用和介入性治疗的广泛应用呈现逐年上升的趋势。其中,白念珠菌是人体内一种最常见的机会型致病真菌,60-70%侵入性真菌感染是由白念珠菌引起的。本实验室将以探究白念珠菌致病机制为基础来建立致病真菌与宿主互作关系的实验平台(整合遗传学、生物化学、系统生物学和实验动物感染模型),以期找到新的药物靶点来有效对抗真菌的系统性感染。

  主要研究工作包括:1)真菌对宿主体内环境因子的感受器的鉴定和分子机制研究;2)病原真菌从共生菌到致病菌的转换机理;3)真菌的效应因子调控宿主免疫系统的机制;4)真菌耐药机制的研究以及抗真菌药物的筛选。

主持课题项目:
1.
国家自然科学基金委面上项目

2.betvicror伟德app 下载自主科研项目


代表性论文:(*corresponding author,#co-first author)
1.Qiangqiang Sun, Kang Xiong, Yuncong Yuan, Jing Yu, Lianjuan Yang, Chao Shen, Chang Su*, and Yang Lu*. (2019) Inhibiting fungal echinocandin resistance by small-molecular disruption of geranylgeranyltransferase type I activity. Antimicrobial Agents and Chemotherapy: 02406-19


2.Yang Lu*#; Chang Su#; Shatarupa Ray; Yuncong Yuan; Haoping Liu*. (2019) CO2 signaling through the Ptc2-Ssn3 axis governs sustained hyphal development of Candida albicans by reducing Ume6 phosphorylation and degradation. mBio 10(1)


3.Chang Su#; Jing Yu#; Qiangqiang Sun; Qian Liu; Yang Lu*. (2018) Hyphal induction under the condition without inoculation in Candida albicans is triggered by Brg1-mediated removal of NRG1 inhibition. Molecular Microbiology 108(4): 410-423


4.Chang Su; Jing Yu; Yang Lu*. (2018) Hyphal development in Candida albicans from different cell states. Current Genetics 64(6): 1239-1243


5.Chang Su#; Yang Lu#; Haoping Liu. (2016) N-acetylglucosamine sensing by a GCN5-related N-acetyltransferase induces transcription via chromatin histone acetylation in fungi. Nature Communications 7:12916


6.Yang Lu, Chang Su, and Haoping Liu. (2014) Candida albicans hyphal initiation and elongation. Trends in Microbiology 22(12): 707-14.


7.Yang Lu#, Chang Su#, Ohimai Unoje, and Haoping Liu*. (2014) Quorum sensing controls hyphal initiation in Candida albicans through Ubr1-mediated protein degradation. Proc Natl Acad Sci 111(5): 1975-80.


8.Yang Lu, Chang Su, Norma V. Solis, Scott G. Filler, and Haoping Liu*. (2013) Synergistic regulation of hyphal elongation by hypoxia, CO2, and nutrient conditions controls the virulence of Candida albicans. Cell Host & Microbe 14(5): 499-509.


9.Chang Su#, Yang Lu#, and Haoping Liu*. (2013) Reduced TOR signaling sustains hyphal development in Candida albicans by lowering Hog1 basal activity. Molecular Biology of the Cell 24(3): 385-97. (* equal contribution)


10.Yang Lu, Chang Su, and Haoping Liu*. (2012) A GATA transcription factor recruits Hda1 in response to reduced Tor1 signaling to establish a hyphal chromatin state in Candida albicans. PLoS Pathogens 8(4): e1002663.


11.Yang Lu, Chang Su, Allen Wang, and Haoping Liu*. (2011) Hyphal development in Candida albicans requires two temporally linked changes in promoter chromatin for initiation and maintenance. PLoS Biology 9(7): e1001105.


12.Yang Lu, Chang Su, Xuming Mao, Prashna Pala Raniga, Haoping Liu*, and Jiangye Chen*. (2008) Efg1-mediated recruitment of NuA4 to promoters is required for hypha-specific Swi/Snf binding and activation in Candida albicans. Molecular Biology of the Cell 19(10): 4260-72.


招生招聘:
热忱欢迎本科生、硕士生、博士生、博士后加入本实验室。

每年拟接收1-2名本科生,2名硕士生和1名博士生,博士后可以随时联系。



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