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教师简介

李联运
来源:伟德官网 时间:2016-12-26 12:31:29 阅读量:
职称职务:副教授、硕士生导师
学科专业:生物化学和分子生物学
研究方向:表观遗传学与细胞信号转导
实验室位置:生科院5005号房间
联系方式:027-68756620
Email: lilianyun@whu.edu.cn

 


教育经历:
2000-2005  北京大学伟德官网博士
1994-1998  四川大学生物工程系本科


主要工作经历与任职情况:

2009至今  伟德官网副教授
2005-2009  美国美国国立医学院(National Institutes of Health)博士后

承担课程:
动物生物学实验课(本科)


代表性论文(12 out of 23):
1. Ling-Gao Ju, Yuan Zhu, Pin-Ji Lei, Dong Yan, Kun Zhu, Xiang Wang, Qing-Lan Li, Xue-Jing Li, Jian-Wen Chen, Lian-Yun Li*, Min Wu*. TTLL12 Inhibits the Activation of Cellular Antiviral Signaling through Interaction with VISA/MAVS. J Immunol. 2016.[Epub ahead of print](*Authors for correspondence)

2. Shuai-Kun Su, Chun-Yuan Li, Pin-Ji Lei, Xiang Wang, Quan-Yi Zhao, Yang Cai, Zhen Wang, Lian-Yun Li *, Min Wu *. EZH1/SUZ12 complex positively regulates the transcription of NF-κB target genes via interaction with UXT.J Cell Sci. 2016 129(12):2343-53.(*Authors for correspondence)

3. Kun Zhu, Xiang Wang, Lin-Gao Ju, Yuan Zhu, Jie Yao, Yanyi Wang, Min Wu* and Lian-Yun Li*.WDR82 negatively regulates cellular antiviral response by mediating TRAF3 polyubiquitination in multiple cell lines. The Journal of Immunology 2015 195(11):5358-66 (*Authors for correspondence)

4. Jia-DongFan, Pin-JiLei, Jun-YiZheng, XiangWang, Shang-zeLi, HuanLiu, Yi-LeiHe, Zhao-NingWang, GangWei, Xiao-Dong Zhang,Lian-YunLi *, Min Wu *.The selective activation of p53 target genes regulated by SMYD2 in BIX-01294 induced autophagy-related cell death.PLoS One 2015 10(1): e0116782(*Authors for correspondence)

5. Xiang Wang, Lin-gaoJu, Jia-dong Fan, Yan Zhu, Xiao-lanLiu, Kun Zhu, Min Wu*, Lian-yun Li*.Histone H3K4 methyltransferase Mll1 regulates protein glycosylation and tunicamycin-induced apoptosis through transcriptional regulation.BiochimBiophysActa-Molecular Cell Research. 20141843:2592-602. (*Authors for correspondence)

6. Quan-yi Zhao, Jia-dong Fan, Wei Hong,Lian-yun Li*, Min Wu*.Inhibition of cancer cell proliferation by 5-fluoro-2'-deoxycytidine, a DNA methylation inhibitor, through activation of DNA damage response pathway. SpringerPlus2012 1:65.(*Authors for correspondence)

7. Xiang Wang, Kun Zhu, Shang-ze Li, Yi-fang Liao, Run-lei Du, Xiao-dong Zhang, Hong-Bing Shu, An-Yuan Guo, Lian-yun Li*, Min Wu*. MLL1, a Histone H3K4 Methyltransferase, Regulates the Expression of TNF-α-mediated NF-κB Downstream Genes. J. Cell Sci. 2012 125:4058-66.(*Authors for correspondence)

8. Nia Soetandyo, Qiu-yan Wang, Yi-hong Ye*, and Lian-yun Li*. Role of intramembrane charged residues in the quality control of unassembled T-cell receptor -chains at the endoplasmic reticulum. J. Cell Sci. 2010 123:1031-8. (*Authors for correspondence)

9. Lian-yun Li, Nia Soetandyo, Qiu-yan Wang, Yi-hong Ye. The zinc fingerprotein A20 targets TRAF2 to the lysosomes for degradation. BiochimBiophysActa- Molecular Cell Research. 2009 1793:346-53

10. Lian-yun Li, Dale Hailey, Nia Soetandyo, Wei Li, Jennifer Lippincott-Schwartz, Hong-bing Shu, Yi-hong Ye. Localization of A20 to a lysosome-associated compartment and its role in NF-kappaB signaling. BiochimBiophysActa. 2008 1783:1140-9.

11. Lian-yun Li, Liang-hua Bin, Fu Li, Yi Liu, Dan-ying Chen, Zhong-he Zhai and Hong-bing Shu. TRIP6 is a RIP2-associated common signaling component of multiple NF-kappaB activation pathways. J. Cell Sci. 2005 118:555-63

12. Yan-Yi Wang*, Lian-yun Li*, Ke-jun Han, Zhong-he Zhai and Hong-bing Shu. A20 is a potent inhibitor of TLR3- and Sendai virus-induced activation of NF-kappaB and ISRE and IFN-beta promoter. FEBS Letters. 2004 576:86-90. (*Co-first authors)


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