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教师简介

李晓东
来源:伟德官网 时间:2016-12-26 13:26:54 阅读量:
李晓东,博士生导师
伟德官网6008房间,湖北省武汉市珞珈山,430072
联系电话:13886074625
Email:xiaodli@whu.edu.cn

 

主要学习及工作经历
1993/9-1997/7: 北京大学伟德官网,生物化学与分子生物学学士。
1997/9- 2002/9: 美国东北大学(Northeastern University)生物学系,细胞生物学博士。
2002/10-2004/10:哈佛大学医学院,神经学博士后。
2004/12 –: 伟德官网 (动物生理学)。


发表论文情况:
1.Kramer A, Yang FC, Snodgrass P, Li X, Scammell TE, Davis FC, Weitz CJ. Regulation of daily locomotor activity and sleep by hypothalamic EGF receptor signaling. Science. 294:2511-5(2001).

2.Li X, Sankrithi N, Davis FC. Transforming growth factor-alpha is expressed in astrocytes of the suprachiasmatic nucleus in hamster: role of glial cells in circadian clocks. NeuroReport. 13(16):2143-7(2002).

3.Kramer A, Yang FC, Snodgrass P, Li X, Scammell TE, Davis FC, Weitz CJ. Regulation of daily locomotor activity and sleep by hypothalamic EGF receptor signalling. Novartis Found Symp. 253:250-62; discussion 102-9, 263-6, 281-4(2003).

4.Li X, Gilbert J, Davis FC. Disruption of masking by hypothalamic lesions in Syrian hamsters. J Comp Physiol. 191(1):23-30(2005).

5.Li X, Davis FC. Developmental expression of 3 clock genes in the Syrian hamster. Dev Brain Res.158(1-2):31-40 (2005) .

6.Ding Q,Li X*. Neural pathway for fever generation. Neurosci bulletin. 22(6):350-354(2006)

7. Ji Y, Li X*. Cloning and developmental expression analysis of PK2 and PKR2 in the suprachiasmatic nucleus of the Syrian hamster. Brain Res. 1271: 18-26 (2009).

8. Yoshida K,Li X, Cano G, Lazarus M,Saper CB. Parallel preoptic pathways for the inhibition of thermogenesis. J Neurosci.29(38):11954-64 (2009).

9. Ji Y, Qin Y, Shu HB, Li X. Methylation analyses on promoters of mPer1, mPer2 and mCry1 during perinatal development. Biochem Biophys Res Commun. 391(4): 1742-7 (2010).

10.Li C, Yu S, Zhong X, Wu J, Li X. Circadian Rhythms of Fetal Liver Transcription Persist in the Absence of Canonical Circadian Clock Gene Expression Rhythms in vivo. PLoS One. 7(2): e30781 (2012).

11. Li C, Yu S, Zhong X, Wu J, Li X. Transcriptome Comparison between Fetal and Adult Mouse Livers: Implications for Circadian Clock Mechanisms. PLoS One. 7(2): e31292 (2012).

12. Li C, Gong C, Yu S, Wu J, Li X. Epigenetic control of circadian clock operation during development. Genetics Res International. 845429 (2012).

13. Li X, Li C, Gong C, Yu S. Epigenetic Control of Circadian Clock Operation. In “DNA methylation: principles, mechanisms and challenges”. Nova Science Pub Inc.(2013).

14. Wu S, Lv Z, Zhu J, Dong P, Zhou F, Li X, Cai Z. Somatic mutation of the androgen receptor gene is not associated with transitional cell carcinoma: a “negative” study by whole-exome sequencing analysis. Eur Urol. 64(6): 1018-9 (2013).

15: Avp-iCre转基因小鼠的鉴定。 李娟(#); 李晓东(*)湖北师范学院学报(自然科学版), 2015.6.25, (02): 39~43。

16:视交叉上核在昼夜节律中的作用。 程满,余爽,李娟,李晓东《生命科学》2015年11期。

17. Gong C, Li C, Qi X, Song Z, Wu J, Hughes, ME, Li X. The daily rhythms of mitochondrial gene expression and oxidative stress regulation are altered by aging in the mouse liver. Chronobiol Int. 32(9):1254-63 (2015).

18. Hughes ME, Abruzzi KC, Allada R, Anafi R, Arpat AB, Asher G, Baldi P, de Bekker C, Bell-Pedersen D, Blau J, Brown S, Ceriani MF, Chen Z, Chiu JC, Cox J, Crowell AM, DeBruyne JP, Dijk DJ, DiTacchio L, Doyle FJ, Duffield GE, Dunlap JC, Eckel-Mahan K, Esser KA, FitzGerald GA, Forger DB, Francey LJ, Fu YH, Gachon F, Gatfield D, de Goede P, Golden SS, Green C, Harer J, Harmer S, Haspel J, Hastings MH, Herzel H, Herzog ED, Hoffmann C, Hong C, Hughey JJ, Hurley JM, de la Iglesia HO, Johnson C, Kay SA, Koike N, Kornacker K, Kramer A, Lamia K, Leise T, Lewis SA, Li J, Li X, Liu AC, Loros JJ, Martino TA, Menet JS, Merrow M, Millar AJ, Mockler T, Naef F, Nagoshi E, Nitabach MN, Olmedo M, Nusinow DA, Ptá?ek LJ, Rand D, Reddy AB, Robles MS, Roenneberg T, Rosbash M, Ruben MD, Rund SSC, Sancar A, Sassone-Corsi P, Sehgal A, Sherrill-Mix S, Skene DJ, Storch KF, Takahashi JS, Ueda HR, Wang H, Weitz C, Westermark PO, Wijnen H, Xu Y, Wu G, Yoo SH, Young M, Zhang EE, Zielinski T, Hogenesch JB. Guidelines for Genome-Scale Analysis of Biological Rhythms. J Biol Rhythms. 32(5):380-393 (2017).

19. Zhu J, Li C, Gong C, Li X. Regulation of Pol II Pausing Is Involved in Daily Gene Transcription in the Mouse Liver. J Biol Rhythms. 33(4):350-362 (2018). 


研究项目:
1.湖北省杰出科学青年基金(主持)。
2.NSFC30700212(视交叉上核表达的PK2和PKR2基因在金黄地鼠近日节律功能中的研究,2008/1-2010/12。18万元,主持)
3.国家“十一五“重大研究计划“人类重大疾病动物模型的建立”(参与)。
4.教育部博士点/新教师基金。
5. NSFC 重点项目30830112 (2009/1-2012/12。参与)。
6.科技部 “抑郁症的蛋白质组学”项目 (2009/1-2012/12。参与。)
7. NSFC 30970953 (下丘脑内视交叉上核投射区表达的PKR2受体分子在近日节律功能中的作用研究, 2010/01-2012/12。33 万元,主持)。
8. NSFC81271464 (主持,下丘脑MnPO核团神经元的化学表型和投射目标及其与睡眠和体温调控功能关系的系统研究, 2013/01-2016-12。72 万元,主持)
9. 973 “线粒体功能障碍致早期心衰机制及干预策略研究” (2013/1-2017/12,参与)
10. NSFC31471124 (小鼠视交叉上核内VIP,GRP和AVP神经元在昼夜节律功能中的作用研究,2015/01-2018/12。 92 万元,主持)


研究内容介绍
见英文版(Please see the English Version)。


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